GLP-1 drugs like Novo Nordisk’s Ozempic and Eli Lilly’s Mounjaro have become part of the zeitgeist.
With demand still so high, these drugs continue to face shortages that show little sign of easing anytime soon.
There’s even a growing community of “GLP-1 influencers” on social media sites like TikTok, where people who take the drug document their weight loss journeys and build audiences of people who want to try the drugs themselves.
Before all that, though, much of the hype surrounding these new drugs was fueled by celebrities. As the original “influencers,” celebrities have had a profound impact on the GLP-1 narrative since their inception.
Here are some of the top celebrities who have confirmed they’ve tried a GLP-1 drug and what they have to say about it.
There may not be a more popular celebrity associated with weight loss than Oprah.
For decades, the public has followed her weight loss story both on TV and in print. However, that saga took a different turn late last year, with Winfrey admitting that she finally tried GLP-1 drugs after a lifelong struggle with weight and obesity.
In her interview with PeopleWinfrey noted that she initially chose not to try the drug because she wanted to prove she had the will to stick to a diet and exercise plan to lose weight.
After a discussion she hosted as part of her Life You Want series — which featured weight-loss experts and doctors discussing GLP-1 treatments — Winfrey changed her mind.
“I had the biggest aha along with a lot of people in that audience,” she explained People. “I realized that I had blamed myself all these years for being overweight and I have a predisposition that no amount of will will control. Obesity is a disease. It’s not about the will – it’s about the brain.”
Winfrey noted that she “let go of my shame about it” after the panel and asked for a prescription from her doctor, though she did not reveal which medication she was taking.
“Now I use it as I feel I need it, as a tool to manage yo-yo-yoing,” she said.
Winfrey, who noted that she has faced negative scrutiny about her body and weight for decades, said that having a medically approved prescription for weight management “feels like a relief, like redemption, like a gift, and not something to hide behind again and again. ridiculed for.”
“I am absolutely done with being shamed by other people and especially by myself,” she added.
Tesla CEO and Neuralink co-founder Elon Musk was one of the first high-profile celebrities to openly discuss taking GLP-1 drugs.
On X, the social media platform formerly known as Twitter that he owns, Musk tweeted in November 2022 that he was “under 30 pounds!”
When commenters asked what had made the most difference, Musk replied, “Fasting + Ozempic/Wegovy + no yummy food around me.” He also noted that the drug was helping him get “fit, ripped and healthy.”
Actor and comedian Tracy Morgan, who is perhaps best known for his roles Saturday Night Live AND 30 Rocknoted in an interview with Hoda Kotb and Jenna Bush Hager in August 2023 that he was taking Ozempic.
He credited his recent weight loss to Novo Nordisk’s star drug, noting that he gets an injection every Thursday and “I don’t let it go!”
“They cut my appetite in half,” Morgan added and joked, “now I only eat half a bag of Doritos.”
Real Housewives of Orange County star Emily Simpson admitted during a recent discussion on SiriusXM’s Jeff Lewis Live that her doctor encouraged her to try Ozempic.
“So I did it,” she said. “I did this in December for a month.”
She noted that some of her unhealthy eating habits “went away” and that taking the drug “made me more conscious of what I was eating and so that was a really good start for me.”
Simpson has recently lost a significant amount of weight, according to Women’s health, and she attributes much of this to major lifestyle changes. This includes walking 14,000 steps a day, exercising three days a week, dieting and sleeping soundly every night.
She wouldn’t confirm whether she continued Ozempic long-term, though she considered it a “start” to her larger weight loss journey.
While many celebrities are drug addicts, there are critics who have had negative experiences.
Comedian Amy Schumer noted in an interview with Andy Cohen in June 2023 that she had tried the drug, but said the side effects were too much for her.
“I was one of the people who felt sick, I couldn’t play with my son,” she said. “You’re like, ‘OK, that’s not viable for me,’ but I invested right away because I’m like, ‘Everybody and their mother is going to try it.’
Schumer also noted that while many celebrities are opening up about their use of GLP-1, there are countless others who aren’t admitting to using the drug as the key to their weight loss.
“All [is] lying, everyone says, ‘Oh, smaller portions,'” Schumer said. “You’re on Ozempic or one of those things. Be real with people.”
The wife of heavy metal legend Ozzy Osbourne has also been open to trying GLP-1 drugs to help her lose 42 pounds.
However, she says the drugs should be taken with a grain of salt – and ideally supported permanently.
“It does what it says on the package, it absolutely does,” she noted in an interview. “I don’t think it’s for teenagers at all. I fear for 16 to 20 year olds. I think it should be in the hands of people who understand that there can be side effects.”
King Charles is not shy at all when it comes to sharing his opinions and that includes GLP-1.
The NBA Hall of Famer and television analyst noted The Pat McAfee Show last year he was taking Eli Lilly’s Mounjaro – and the effects were beneficial to him.
He said he lost 60 pounds in six months on the drug as part of his overall weight loss plan that included healthy eating and exercise.
“It’s been amazing,” Barkley said when asked about the effects of the drug. “My doctor, she is wonderful. I know a lot of people take Ozempic, but my doctor prefers Mounjaro.”
Former UK Prime Minister Boris Johnson also didn’t have the best experience trying GLP-1 drugs, but in an article in Daily Mailhe noted that semaglutide could be a “wonder drug” for other people.
Johnson first came across GLP-1 when he noticed a cabinet member had lost a significant amount of weight, which inspired him to want to try the “magic drug” as well.
“I would seek the hero within me,” Johnson wrote, “the one who was three stone lighter. I would find the agile and dynamic version of Johnson, imprisoned for decades in senseless extra body weight, and set him free the free one.”
Johnson sought advice from his doctor, who gave him Ozempic — and “hey presto — no more raiding the fridge at 11:30 p.m. for cheddar and chorizo washed down with half a bottle of wine,” Johnson wrote.
“For weeks I pounded my stomach,” Johnson continued, “and for weeks it worked.” He lost four to five pounds a week and saw his appetite diminish.
However, then the side effects set in, as the injections began to leave him with a sense of regret. Johnson eventually decided to stop taking Ozempic because of these side effects.
“At the moment I’m back to exercise and willpower, but I look at my colleagues – leaner, but no longer hungry – and hope that if science can do this for them, maybe one day it can help me and everyone others.”