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The force was with Lab St-Pierre this week. “We finally achieved a dream I had 10 years ago,” the lab tweeted, sharing a link to their new paper on Cell that describes EAT-2Pa genetically encoded strain indicator (GEVI).
We finally achieved a dream I had 10 years ago: sustained (> 30 min) deep-tissue imaging (> 400 um deep) of rapid voltage dynamics (eg, burst firing) in the brain of clever mice. Check out our newsletter on *Cell* here: https://t.co/empIhzY4Gu
— St-Pierre Lab (@StPierreLab) August 22, 2022
The researchers concluded that the protein-based biosensor “addresses a critical need in neuroscience: the noninvasive recording of fast voltage transients for extended durations and in deep cortical layers.”
The vehicle belongs to a GEVI family that have “a bright future,” wrote Michael Lin, an associate professor of neurobiology and bioengineering at Stanford University, in a tweet of the quote.
Congratulations François for the beautiful work! From your first ASAP1 result it was clear that the GEVIs of the ASAP family had a bright future… And that ASAP1 would spawn many useful variants
Your announcement is also timely for my new Twitter account https://t.co/Ji67c9ZNBO
— Michael Lin (@MichaelLinLab) August 23, 2022
Katrin Franke, junior research group leader at the University of Tübingen in Germany, congratulated the team on Twitter, adding “glad to have contributed the retinal part to this big project /w @AnnaIntegrated/@mkorympidou. Try it available at Addgene!”
compliments @StPierreLab et al. for the development of JEDI2P, a new strain indicator for stable and deep tissue imaging published in @CellCellPress????Glad to contribute the retina part to this great project /w @AnnaIntegrated/@mkorympidou. Try it available at Addgene! https://t.co/RVchH7Okyv
— Katrin Franke (@kfrankelab) August 22, 2022
The sensor is “screened and optimized for #Microscope with two photos – perfect for extremely fast AOD imaging,” tweeted Harvard postdoctoral fellow Fabian Voigt.
@StPierreLab introduces JEDI-2P: A Genetically Encoded Controlled and Optimized Two-Photon Voltage Indicator #Microscope – perfect for quick AOD images from @DieudonneLab! https://t.co/yGM9WgBP6y https://t.co/z06wmndilI pic.twitter.com/7yMfYF2PCq
— Fabian F. Voigt (@voigtvision) August 22, 2022
In a separate tweet, Brittany Hand, assistant professor of health and rehabilitation sciences at Ohio State University in Columbus, shared her new review paper that lists five ways providers can meet autistic people. mental health needs.
See our new review paper showing that autistic adults frequently use mental health services but continue to have unmet mental health needs. We list 5 practical ways providers can better meet these population needs! Read-only link for full text: https://t.co/J5B5Py9cfF pic.twitter.com/IyDoSGu0QI
— Dr. Brittany N. Hand (@BN_Hand) August 23, 2022
“Very necessary and practical suggestions!” tweeted Meng-Chuan Lai, assistant professor of child and adolescent psychiatry at the University of Toronto in Canada.
Much needed and practical suggestions! https://t.co/ZcV7OqCUGm
— Meng-Chuan Lai (@mengchuanlai) August 23, 2022
“Mental health support is consistently identified as a key need for autistic people,” wrote Patrick Jachyra, assistant professor of sport and exercise science at Durham University in the UK, adding that people with autism do not get the mental health support they need.
Such important work, thanks for sharing!! Mental health support is consistently identified as a major need among autistic people, but is consistently lacking in a number of jurisdictions around the world, Canada, the US, the UK, etc. https://t.co/uDtQdzeekJ
— Patrick Jachyra (@PatrickJachyra) August 23, 2022
On another topic, Steven Kapp, an autistic lecturer in psychology at the University of Portsmouth in the UK, shared a comment of the benefits and harms of interventions to improve mental health outcomes for autistic people published in Autism.
The review of interventions to treat autistic mental health concludes against treating “core features of autism” to improve mental health, rather than mental health directly. However, evidence for specific interventions for autistics with poor mental health is lacking https://t.co/3Wjzr1nGku
— Steven Kapp (@drstevenkapp) August 19, 2022
Kapp noted that the review “ends against addressing ‘core features of autism’ to improve mental health, rather than mental health directly.”
“This will be one slow, careful reading coffee in hand,” wrote Sarah Edmunds, assistant professor of psychology at the University of South Carolina, in a tweet. She then added “We need more evidence if our EBTs for neurotypical people with anxiety, depression and trauma work as well (and in the same way) for autistic people with these mental health challenges.”
This will be a slow, careful read with coffee in hand. We need more evidence if our EBTs for neurotypical people with anxiety, depression, and trauma work as well (and in the same way) for autistic people with these mental health challenges. https://t.co/uHL7ItiJPk
— Sarah Edmunds, PhD (@SarahREdmunds) August 19, 2022
Finally, Noah Sasson, professor of psychology at the University of Texas at Dallas, shared a study that appeared in Autism Research, whose findings suggest that using the Autism Diagnostic Observation Schedule to confirm autism diagnoses for enrollment in research studies leads to an underrepresentation of girls participating in those studies. “Relying on community diagnosis rather than confirmatory diagnostic assessments resulted in more equal gender ratios“, he wrote on Twitter.
“Using the ADOS as a confirmatory diagnostic measure resulted in the exclusion of autistic females at a rate over 2.5 times that of autistic males. . . . Relying on community diagnosis rather than confirmatory diagnostic assessments resulted in higher rates of gender equality.” https://t.co/N7PJCs3p0p
— Noah Sasson (@Noahsasson) August 22, 2022
“ADOS-2 a fix is long overdue be suitable for diagnosis in women,” tweeted Bianca Schuster, a postdoctoral fellow in philosophy at Waseda University in Tokyo.
The ADOS-2 is a long overdue update to be suitable for diagnosing women. I have often found the very items that are not used for the final diagnosis are the ones where women score high… https://t.co/IQUb8ujaBL
— Bianca Schuster (@BiancaASchuster) August 23, 2022
“More evidence supports the need to rethink nuanced autistic presentations and assess sex-based measurement bias,” wrote Catherine Burrows, assistant professor of pediatrics at the University of Minnesota in Minneapolis.
Really interesting article showing that the rate of ASD diagnosed is not the same as the rate of people meeting the diagnostic threshold on the ADOS. More evidence supporting the need to rethink nuanced autism presentations and assess sex-based measurement bias. https://t.co/AmqZ764uSR
— Casey Burrows, PhD, LP (@CaseyBurrowsPhD) August 22, 2022
That’s it for this week’s Community Newsletter! If you have any suggestions for interesting social posts you’ve seen in the field of autism research, feel free to send an email to [email protected].
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